NAGEL NORBERT,BAUMGARTNER BRUNO,BERCHTOLD HARALD,PLETTENBURG OLIVER,KADEREIT DIETER,MOHNICKE MANDY,GESSLER SIMON,TILLNER JOACHIM
申请号：
NZ62086412
公开号：
NZ620864A
申请日:
2012.06.27
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed herein are crystalline solvates of 6-(piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride, processes for their preparation and the use thereof in the manufacture of medicaments for the treatment of conditions selected from the group consisting of hypertension, pulmonary hypertension, ocular hypertension, retinopathy, glaucoma, peripheral circulatory disorder, peripheral occlusive arterial disease (PAOD), coronary heart disease, angina pectoris, heart hypertrophy, heart failure, ischemic diseases, end organ damage, fibroid lung, fibroid liver, liver failure, nephropathy, renal failure, fibroid kidney, renal glomerulosclerosis, organ hypertrophy, asthma, chronic obstructive pulmonary disease (COPD), adult respiratory distress syndrome, thrombotic disorders, stroke, cerebral vasospasm, cerebral ischemia, pain, neuronal degeneration, spinal cord injury, Alzheimer&rsquos disease, premature birth, erectile dysfunction, endocrine dysfunctions, arteriosclerosis, prostatic hypertrophy, diabetes and complications of diabetes, metabolic syndrome, blood vessel restenosis, atherosclerosis, inflammation, autoimmune diseases, osteopathy, infection of digestive tracts with bacteria, sepsis or cancer development and progression.
