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FGF RECEPTOR ACTIVATOR N-SULFATE OLIGOSACCHARIDES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
专利权人:
SANOFI AVENTIS
发明人:
PHILIPPE DUCHAUSSOY,PIERRE FONS,ALEXANDRE FROIDBISE
申请号:
FR0903969
公开号:
FR2949115B1
申请日:
2009.08.14
申请国别(地区):
FR
年份:
2012
代理人:
摘要:
The invention relates to FGF receptor-activating N-sulfate oligosaccharides having Formula (I), wherein R1, R4, R6, and R8 are —OSO3− or hydroxyl groups, R2 is an —O-alkyl group or a monosaccharide having Formula (II), R3 is a disaccharide having Formula (III), R5 is a disaccharide having Formula (IV), R7 is a hydroxyl group or a disaccharide having Formula (VI), and R9 is a hydroxyl or —O-alkyl group or a disaccharide having Formula (VII), where R10- is an —O-alkyl group. The invention further relates to the preparation of said oligosaccharides and to the therapeutic use thereof.
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