method of preparation of azilsartan medoxomil potassium salt, solvate, and azilsartan medoxomil potassium salt

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专利权人:

ZENTIVA; K.S.

发明人:

Jan Stach,Josef Cerny,Ludek Ridvan,Lukas Krejcik,Ondrej Dammer,Radim Krulis,Stanislav Radl

申请号：

BR112015006572

公开号：

BR112015006572A2

申请日:

2013.09.25

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “method for the preparation of azilsartan medoxomil potassium salt, solvate, and azilsartan medoxomil potassium salt” is a preparation method for the preparation of potassium azilsartan medoxomil of formula i, where noo nk (i) ooooo where a azilsartan medoxomil solvate of formula ii or noo nh (ii) ooooo with a solvent selected from the group consisting of dimethyl acetamide or n- Methyl pyrrolidone or mixtures thereof with other solvents is prepared, or recrystallized from dimethyl acetamide or n-methyl pyrrolidine or mixtures thereof with other solvents, and, in the next step, converted to potassium salt. through a potassium source in a suitable solvent.1 / 1 resumo “mã‰todo para preparaã‡ãƒo do sal de potã�ssio de azilsartan medoxomil, solvato, e, sal de potã�ssio de azilsartan medoxomilâ€� um mã©todo de preparaã§ã£o do sal de potã¡ssio de azilsartan medoxomil de fã³rmula i, o n o o nk n n (i) o o o o o em que um solvato de azilsartan medoxomil de fã³rmula ii o n o o nh n n (ii) o o o o o com um solvente selecionado a partir do grupo que consiste em dimetil acetamida ou n-metil pirrolidona ou as misturas dos mesmos com outros solventes ã© preparado, ou re-cristalizado a partir de dimetil acetamida ou n- metil pirrolidina ou as misturas dos mesmos com outros solventes, e, na etapa seguinte, convertido no sal de potã¡ssio atravã©s de uma fonte de potã¡ssio, em um solvente adequado.

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