Memorial Sloan Kettering Cancer Center;Cornell University
发明人:
Michelle S. Bradbury,Barney Yoo,Ulrich Wiesner,Kai Ma
申请号：
US16653490
公开号：
US20200289668A1
申请日:
2019.10.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and/or treatment.
