Martyn David Ticehurst;Ivan Marziano;Eleftherios Kougoulos
发明人:
Martyn David Ticehurst,Ivan Marziano,Eleftherios Kougoulos
申请号：
US14131407
公开号：
US10370402B2
申请日:
2012.07.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention relates to a novel crystallization process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronization. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then adding this solution to water or to a mixture of water 10 and acetone, thereby causing fluticasone propionate to crystallize out of the solution as crystalline form.
