Yizhou Dong,Akinleye C. Alabi,Hao Yin,Joseph R. Dorkin,Delai Chen,Robert S. Langer,Daniel Griffith Anderson,Ahmed A. Eltoukhy
申请号：
US14267530
公开号：
US09315472B2
申请日:
2014.05.01
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.
