In the present invention, by administering a liposome containing pyranosyl ceramide compound, which is an unaltered NKT cell ligand, IL-21 production by iNKT cells is locally induced in the vicinity of IgE-producing B cells of the splenic marginal zone, apoptosis of these IgE-producing B cells is induced, and the like, and IgE production of IgE-producing B cells of the splenic marginal zone is effectively controlled.藉由投與含有不變NKT細胞配位子之吡喃糖基神經醯胺化合物的微脂體,於脾臟邊緣區之產生IgE之B細胞的附近局部地誘導iNKT細胞之IL-21產生,且誘導該產生IgE之B細胞之細胞凋亡等,以有效地抑制脾臟邊緣區產生IgE之B細胞之IgE產生。
