Disclosed are engineered cardiac tissues. The tissues include cardiomyocyte cells derived from a pluripotent cell, fibroblast cells and extracellular matrix components. The growth ability of the fibroblast cells may be limited. The tissue contracts coherently or synchronously with electrical pacing by an external electrical stimulator. Methods of using the tissues described herein are also provided.Linvention porte sur des tissus cardiaques artificiels. Les tissus comprennent des cellules de cardiomyocytes dérivées à partir dune cellule pluripotente, des cellules de fibroblastes et des composants de matrice extracellulaire. Linvention porte également sur des procédés dutilisation des tissus décrits ici.
