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NON-HUMAN ANIMALS HAVING A MUTANT KYNURENINASE GENE
专利权人:
REGENERON PHARAMACEUTICALS; INC.
发明人:
KYRATSOUS, CHRISTOS,MUJICA, ALEXANDER O.
申请号:
CA3014208
公开号:
CA3014208A1
申请日:
2017.02.16
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a mutant L-kynurenine hydrolase (or kynureninase) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification in an endogenous kynureninase gene so that said non-human animals express a kynureninase polypeptide that includes an amino acid substitution that results in the elimination of an epitope in said kynureninase polypeptide that is present in the membrane proximal external region of human immunodeficiency virus- 1 gp41.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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