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ANTIBODY AGAINST HUMAN PROSTAGLANDIN E2 RECEPTOR EP4
专利权人:
发明人:
申请号:
EP11829187.1
公开号:
EP2623594B1
申请日:
2011.09.28
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
It is an object of the present invention to provide an antibody that binds to a human PGE2 receptor subtype EP4 and inhibits the function of EP4, or a functional fragment thereof. It is another object of the present invention to provide a medicament comprising the aforementioned antibody or a functional fragment thereof. Mice were immunized with the human PGE2 receptor subtype EP4, and a monoclonal antibody that suppresses the intracellular cAMP level increase induced by EP4 was screened. In addition, the CDR sequences of the obtained monoclonal antibody were determined.
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