antibody or macromolecule antigen binding fragment, nucleic acid molecule, pharmaceutical composition, antigen, and methods for making an antibody and for selecting an antibody.
The invention relates to antibodies directed against cd127, the alpha chain of interleukin 7 (il-7) il-7r) receptor, and which have antagonistic properties for il-7-yl-7r interaction, may exhibit cytotoxic activity against cells. positive for cd127, but do not increase tslp-induced dendritic cell (dcs) maturation, a cytokine that also uses cd127 as part of its receptor. alternatively or additionally, such antibodies do not induce cd127 internalization and / or inhibit cd127 il-7 induced internalization. According to another aspect of the invention, antibodies are provided which recognize a human cd127 epitope comprising sequences from cd127 site 2b, in particular the epitope comprising human cd127 sequences from domain d1 and cd127 site 2b, in particular the epitope comprises at least one d1 sequence comprising sequence id: 115 (in particular comprising sequence id: 110 and / or sequence id: 111 and / or a site 2b sequence comprising sequence of 116 and optionally also comprises: 117 (in particular comprises: 111) The antibodies of the invention are suitable for use in medicating a condition diagnosed in a human patient that results in of lymphopoiesis-related pathogenesis, when the il-7 signaling pathways provide contribution to said pathogenesis, especially when an increase in maturation, more precisely the increasing regulation of cohesive molecules. of dendritic cells is undesirable.a invenção refere-se a anticorpos direcionados contra cd127, a cadeia alfa do receptor de interleucina 7 (il-7) il-7r) e que têm propriedades antagonistaas para a interação il-7-il-7r, podem apresetnar atividade citotóxica contra células positivadas para cd127, mas não aumentam a maturação de células dendríticas (dcs) induzida por tslp, uma citocina que também usa cd127 como parte de seu receptor. alternativa ou adicionalmente, esses anticorpos não induzem a internalização de cd127 e/ou inibem a internalização induzida por il-7 de cd127. de acordo com outro aspecto da invenção, são f
