A control system for a thermoregulation assembly includes a fluid manifold assembly (12') and a control unit (56'). The fluid manifold assembly includes a manifold output (26) for supplying thermoregulation fluid to an interface pack. The manifold assembly is operable to selectively provide thermoregulation fluid into the interface pack in accordance with feed parameters. The control unit (56') can obtain a desired temperature profile and a conversion algorithm, the conversion algorithm providing a formula for deriving one of more feed parameters for bringing the interface pack to or maintaining the interface pack at a desired temperature dependent upon a characteristic energy transfer rate between a user and the interface pack. The control unit (56') is operable to calculate one or more feed parameters from the desired temperature profile and the conversion algorithm and to operate the manifold assembly (12') in accordance with the one or more feed parameters.
