A safety isolation bag for intra-abdominal, endoscopic procedures, power morcellation and vaginal morcellation to facilitate the safe removal of surgical specimen or body mass within the abdominal cavity is disclosed. It is an inflatable pneumoperitoneum device comprising an expandable and collapsible enclosed internal space or cavity (5) formed by one or more layers of flexible biocompatible / medical grade plastic material, having a neck portion (4) with a mouth (3), and normally kept in opened position by means of a flexible retainer ring (7) embedded at upper circumferential portion of the mouth. One or more non-return valves are provided along the walls of the safety isolation bag for introducing the surgical instruments and accessories into the enclosed internal space or cavity (5). A retractor means (2) attached to the periphery of the mouth of the bag facilitates pulling out the bag through the incision made in the body. Fig.1
