Francisco Villa;Jennifer Smith;William Gerwick;Lena Gerwick;Huykjae Choi;David C Rowley
发明人:
William Gerwick,Lena Gerwick,Huykjae Choi,Francisco Villa,Jennifer Smith,David C Rowley
申请号：
US13696583
公开号：
US20140147481A1
申请日:
2011.06.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
