PROBLEM TO BE SOLVED: To provide a superior therapeutic agent for prostate cancer, which combines a therapeutic agent for prostase cancer and a tyrosine kinase inhibitor and can inhibit a change from hormone-dependent prostate cancer to hormone-independent prostate cancer.SOLUTION: The combined drug is a preventive-therapeutic agent obtained by combining a therapeutic agent for prostase cancer and a tyrosine kinase inhibitor.COPYRIGHT: (C)2012,JPO&INPIT【課題】前立腺癌治療薬とチロシンキナーゼ阻害薬とを組み合わせてなる、ホルモン依存性前立腺癌のホルモン非依存性癌への変化を抑制することによる優れた前立腺癌治療薬の提供。【解決手段】前立腺癌治療薬とチロシンキナーゼ阻害薬を組み合わせてなる前立腺癌の予防・治療剤。【選択図】なし