Yi Seed by Wei Li System at Drug Wu Group close object,The particle at least closes object in a Duan Fu Cover Suo Shu Group with what and injects the 6th Ge month Time Inter Li Slow Buddhism Huo Wu Quality of Hou,Suo Shu Group close object include Yi Group by PLGA Class type Gong Ju Wu System at particle,The particle Erbium-doped enters to have the Huo Wu Quality of water-insoluble Tai Which form; And the copolymer includes at least 75 lactic acid and 0.1-0.The intrinsic viscosity of 9dl/g Inter,The viscosity is 0.Under the polymer Concentrated degree of 5g/dL in chloroform Measuring amount Xia 25 C; And there is under the particle Suo to Ding the distribution of grain size of Righteousness: D (v,0.1) in 10-30 micron Inter,D(v,0.5) in 30-70 micron Inter,D(v,0.9) in 50-110 micron Inter.一種由微粒製成的藥物組合物,所述微粒用於至少在一段覆蓋所述組合物注射後第6個月的時間裏緩釋活性物質,所述組合物包含一組由PLGA類型的共聚物製成的微粒,所述微粒摻入有水不溶性肽鹽形式的活性物質;而且所述共聚物包含至少75的乳酸和0.1-0.9dl/g之間的特性黏度,該黏度是在0.5g/dL的聚合物濃度下在氯仿中25˚C下測量;而且所述微粒具有如下所定義的粒度分佈:D(v,0.1)在10-30微米之間,D(v,0.5)在30-70微米之間,D(v,0.9)在50-110微米之間。