Institute For Cancer Research D/b/a The Research Institute of Fox Chase Cancer Center
发明人:
申请号：
EP14847598.1
公开号：
EP3052655B1
申请日:
2014.09.30
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.
