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PANICEIN COMPOUNDS, COMPOSITIONS AND USES THEREOF
专利权人:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE NICE SOPHIA ANTIPOLIS
发明人:
ISABELLE MUS-VETEAU,OLIVIER THOMAS,MARIE-AUDE TRIBALAT,STÉPHANE AZOULAY
申请号:
US15522300
公开号:
US20170326076A1
申请日:
2015.10.26
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention relates to the fields of medicine and cancer treatment. The invention more specifically relates to the use of a panicein or a derivative thereof, to decrease or inhibit, in vitro or ex vivo, the Patched receptor drug efflux activity, in particular the chemotherapeutic drug efflux activity and chemotherapy resistance. The present disclosure further relates to uses of such compounds, in particular to prepare a pharmaceutical composition to allow or improve the efficiency of a therapy of cancer in a subject in need thereof. The compound of the invention can indeed be advantageously used, in combination with at least one chemotherapeutic drug, for treating cancer, for preventing cancer metastasis and/or for preventing cancer recurrence in a subject. The invention also discloses methods for preventing or treating cancer, cancer metastasis and/or cancer recurrence in a subject, as well as kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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