PROBLEM TO BE SOLVED: To provide a recombinant antibody that is an antibody used for the treatment of prostate cancer and binds to prostate-specific stem cell antigen (PSCA).SOLUTION: According to the present invention, an antibody comprises complementarity-determining regions (CDRs) having specific amino acid sequences: CDRs of the variable region of a light chain, CDR1, CDR2, and CDR3 and CDRs of the variable region of a heavy chain, CDR1, CDR2, and CDR3, and binds to prostate-specific stem cell antigen. In the antibody, preferably, the variable region comprises a humanized aminated sequence. According to the present invention, in particular, the antibody can be used as a medicinal product for the treatment of tumor diseases, or as a diagnostic agent. The antibody is suitable for use in the areas of medicine, pharmacy, and biomedical researches.SELECTED DRAWING: Figure 4【課題】前立腺癌の治療に用いる抗体であって、前立腺特異幹細胞抗原（ＰＳＣＡ）に結合する組換え抗体の提供。【解決手段】以下のアミノ酸配列：軽鎖可変領域のＣＤＲ：ＣＤＲ１、ＣＤＲ２、ＣＤＲ３及び重鎖可変領域のＣＤＲ：ＣＤＲ１、ＣＤＲ２、ＣＤＲ３の各々の特定のアミノ酸配列を含む相補性決定領域（ＣＤＲ）を含有する前立腺特異幹細胞抗原に結合する抗体。前記可変領域がヒト化アミノ化配列を含むことが好ましい、抗体。特に、腫瘍疾患を治療するための医薬品として、又は診断薬としての使用も含む抗体。この抗体は、医学、薬学、および生物医学研究の分野での使用に適している。【選択図】図４
