To provide recombinant antibodies that bind to prostate specific stem cell antigen (PSCA) which are therapeutically effective at a low concentration and effectively lyse PSCA positive tumor cells, and uses thereof as pharmaceuticals and diagnostic agents.SOLUTION: Disclosed herein is a recombinant antibody that binds to PSCA, of which complementarity determining region (CDR) comprises: CDR1, CDR2 and CDR 3 of a light chain variable region each having a specific amino acid sequence and CDR1, CDR2, CDR3 of a heavy chain variable region each having a specific amino acid sequence.SELECTED DRAWING: Figure 4【課題】前立腺特異幹細胞抗原（ＰＳＣＡ）に結合する組換え抗体で、低い濃度で治療上有効であり、かつＰＳＣＡ陽性腫瘍細胞を効果的に溶解することができる組換え抗体及びその医薬品、診断薬としての使用の提供。【解決手段】特定のアミノ酸配列を有す：軽鎖可変領域の相補性決定領域（ＣＤＲ）：ＣＤＲ１、ＣＤＲ２、ＣＤＲ３および重鎖可変領域のＣＤＲ：ＣＤＲ１、ＣＤＲ２、ＣＤＲ３を含むＣＤＲを含有する、ＰＳＣＡに結合する組換え抗体。【選択図】図４
