The present invention relates to the generation of a 3D blood vessel model in an area of interest of an object. The present invention is particularly a medical imaging system and method for generating a 3D blood vessel model in an area of interest of an object, and computer program element and computer readable medium for generating a 3D blood vessel model of the region of interest of the object It relates to the body. In order to facilitate and improve the generation of a 3D vascular model of the objects interest area, a step of acquiring at least two 2D x-ray projected images of contrast enhanced vascular structures from different viewing angles, to each of the 2D X-ray projection images Determining the probability map of the default vascular features to determine the probability map for each of the 2D x-ray projected images for the purpose of dialogue, one of the two 2D x-ray projected images by the users interaction By dividing the interest vessel by directing the location of the set of first interest regions to said probability map of the image of said, said at least two 2D X-raysA method of determining and displaying an epipolar line for a location of a set of interest points in said probability map of the other image of the projected image, the second report to the probability map of the other image of the at least two 2D x-ray projected images by the user This is the step of directing the location of the set of comfort points, wherein the epipolar line acts as an orientation, and the second set of points corresponds to the indicated first point, directing the location of the said comfort point, the best of the vascular structure Also determining the associated default features and extracting the 2D centerline, branching point and \/ or blood vessel boundary of this vascular structure from the features of the determined vascular structure, and from the center line, branching point, and \/ or blood vessel boundary of said extracted 2D blood vessel A medical im
