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ADSORBANT POUR ADMINISTRATION PAR VOIE ORALE, MÉDICAMENT POUR MALADIE RÉNALE, ET MÉDICAMENT POUR MALADIE DU FOIE
专利权人:
KUREHA CORPORATION
发明人:
SONOBE, NAOHIRO,WAKAHOI, TAKASHI,AKITA, TAKAHIRO
申请号:
EP14754624
公开号:
EP2959906A4
申请日:
2014.02.24
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
An object of the present invention is to provide an orally administered adsorbent capable of adsorbing large quantities of tryptophan or indoxyl sulfate in the presence of bile acid. The problem can be solved by an orally administered adsorbent comprising spherical active carbon having bulk density from 0.30 to 0.46 g/mL, specific surface area determined by the Brunauer-Emmett-Teller (BET) method of not less than 2000 m 2 /g, total acid group content of less than 0.30 meq/g, pore volume of pore diameter from 20 to 10,000 nm of not more than 0.21 mL/g; and a micropore volume ratio (Vm) of not less than 1.0, determined by Formula (1): Vm = (V 2.0 -V 1.1 )/(V 1.1 -V 0.64 ) (1) [in Formula (1), V 2.0 , V 1.1 , and V 0.64 are cumulative pore volumes of pore diameters not greater than 2.0 nm, not greater than 1.1 nm, and not greater than 0.64 nm, respectively, calculated by the SF method from nitrogen adsorbed quantity].
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