您的位置: 首页 > 农业专利 > 详情页

Pirazoninone derivatives as stimulators of insulin secretion, methods for obtaining and using them for the treatment of diabetes
专利权人:
MERCK PATENT GMBH
发明人:
BOTTON, GÉRARD,KERGOAT, MICHELINE,CHARON, CHRISTINE,ELBAWAB, SAMER
申请号:
ES09718204
公开号:
ES2543598T3
申请日:
2009.01.15
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of general formula (I) ** Formula ** where: n>; = 2; R1 is selected from alkyl, alkenyl and alkynyl, which may be optionally substituted with one or more substituents selected from Y; R2 is hydrogen; R3 is selected from hydrogen, halogen and aryl; wherein the aryl may be optionally substituted with one or more substituents selected from Y; R4 is selected from: - arylalkyl, aryloxyalkyl, which may be optionally substituted with one or more substituents selected from Y; ** Formula ** where: m>; = 1-6; R7 and R8 together constitute a heterocycle; the heterocycle may include one or more heteroatoms from N, O and S; And it is selected from: hydroxy, thio, halogen, cyano, trifluoromethoxy, trifluoromethyl, carboxy, carboxymethyl, carboxy ethyl, alkyl, alkoxy, alkylamino, aryl, arylsulfonylalkyl, aryloxy, arylalkoxy, amino, NR5R6, azido, nitro, guanidino, amidino phosphino , oxo, carbamoyl, alkylsulfonyl, alkylsulfinyl, alkylthio, two Y groups can form a methylenedioxy; where R5 and R6 are independently selected from: hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl; wherein the alkyl, aryl and heteroaryl groups may be optionally substituted with one or more substituents selected from Y; R5 and R6 together may constitute a heterocycle; the heterocycle may include one or more heteroatoms from N, O and S; as well as their racemic forms, tautomers, enantiomers, diastereomers, epimers and polymorphs, and mixtures thereof, and pharmaceutically acceptable salts thereof.Un compuesto de fórmula general (I)**Fórmula** donde: n >;= 2; R1 se selecciona entre alquilo, alquenilo y alquinilo, que pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados entre Y; R2 es hidrógeno; R3 se selecciona entre hidrógeno, halógeno y arilo; donde el arilo puede estar opcionalmente sustituido con uno o más sustituyentes seleccionados entre Y; R4 se selecciona entre: - arilalquilo, ariloxialquilo, que pueden estar opcionalmente sustituidos con uno
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充