A method and system for determining ablation parameters for ablating a tissue is disclosed. In one embodiment, a method comprises determining thickness of a tissue to be ablated. The method further comprises selecting ablation temperature from a range of ablation temperature values pre-defined for the tissue to be ablated. The method comprises determining tissue temperature optimal for effective lesion formation through the entire thickness of the tissue, wherein the optimal tissue temperature corresponds to the selected ablation temperature. Moreover, the method comprises determining optimal time duration needed for the effective lesion formation through the entire thickness of the tissue at the optimal tissue temperature.