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OLIGONUCLÉOTIDE DE TRIPHOSPHATE 5' AVEC EXTRÉMITÉ FRANCHE ET UTILISATIONS ASSOCIÉES
专利权人:
Rheinische Friedrich-Wilhelms-Universität Bonn
发明人:
申请号:
EP19174691.6
公开号:
EP3581656A1
申请日:
2008.05.21
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The oligonucleotide of the present invention has a double-stranded section of at least 21bp, at least one 5' triphosphate, and at least one blunt end which bears a 5' triphosphate. The present invention further provides the use said oligonucleotide for inducing an anti-viral, in particular, an IFN, response in vitro and in vivo. The present invention additionally provides the use of said oligonucleotide for preventing and/or treating diseases or conditions such as infections, tumors/cancers, and immune disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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