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Oligonucléotide de triphosphate 5 avec extrémité franche et utilisations associées
专利权人:
Hartmann; Gunther
发明人:
申请号:
EP12004666.9
公开号:
EP2518150A3
申请日:
2008.05.21
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The oligonucleotide of the present invention has a double-stranded section of at least 21 bp, at least one 5' triphosphate, and at least one blunt end which bears a 5' triphosphate. The present invention further provides the use said oligonucleotide for inducing an anti-viral, in particular, an IFN, response in vitro and in vivo. The present invention additionally provides the use of said oligonucleotide for preventing and/or treating diseases or conditions such as infections, tumors/cancers, and immune disorders.
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