USP47 inhibitors and methods to induce apoptosis
- 专利权人:
- 发明人:
- Michele Pagano,Jeffrey R. Skaar,Angelo Peschiaroli,N. Valerio Dorrello
- 申请号:
- US13668969
- 公开号:
- US08778905B2
- 申请日:
- 2012.11.05
- 申请国别(地区):
- US
- 年份:
- 2014
- 代理人:
- 摘要:
- The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates to methods and kits to screen for related agents that induce apoptosis. Additionally, the invention relates to assays for screening compounds capable of acting as USP47 inhibitors.
- 来源网站:
- 中国工程科技知识中心
相关发明人
相关专利
- USP47 Inhibtors and Methods to Induce Apoptosis
- CELL DEATH INDUCING AGENT FOR CELLS HAVING BRAF GENE MUTATION, AGENT FOR INHIBITING PROLIFERATION OF SAID CELLS, AND PHARMACEUTICAL COMPOSITION FOR TREATING DISEASE CAUSED BY ABNORMAL PROLIFERATION OF SAID CELLS
- Cell death inducing agent for cells having BRAF gene mutation, agent for inhibiting proliferation of said cells and pharmaceutical composition for treating patient suffering from effects of abnormal proliferation of said cells
- BRAF CELL DEATH INDUCING AGENT FOR CELLS HAVING BRAF GENE MUTATION AGENT FOR INHIBITING PROLIFERATION OF SAID CELLS AND PHARMACEUTICAL COMPOSITION FOR TREATING PATIENT SUFFERING FROM EFFECTS OF ABNORMAL PROLIFERATION OF SAID CELLS
- PROTEINES DE FUSION COMPRENANT UNE PROTEASE NON CYTOTOXIQUE, UNE FRACTION DE CIBLAGE, UN SITE DE CLIVAGE DE LA PROTEASE ET UN DOMAINE DE TRANSLOCATION