As for this invention, from the group which consists of the rachis organization, the dura mater and the spinal nerve of the mammal being the cell ingrowth and method in order to prevent the adhesion, and tissue formation after the technique in the surface which receives the injury of the organization which is selected or after the external wound was led of the organization playback which is controlled, of dealing with deficiency in method, and the mammal which include the process where organism activity, it offers the organism functional non porous microscopic multilayer collagen foil living thing substrate vis-a-vis organization, covers with that, separates with that being the method, vis-a-vis the aforementioned organization, organism activity, organism functional non porous microscopicIt offers the mark multilayer collagen foil living thing substrate, covers with that, it regards the method of including the process which is separated with that.本発明は、哺乳動物の脊柱組織、硬膜及び脊髄神経からなる群より選択される組織の傷害を受けた表面における術後又は外傷後癒着、及び線維形成を防止するための導かれた細胞内殖及び制御された組織再生の方法であって、組織に対して、生体活性、生体機能性の非多孔性微視的多層コラーゲンホイル生物基質を提供し、それで覆い、それで分離する工程を含む方法、並びに、哺乳動物において欠損を処置する方法であって、前記組織に対して、生体活性、生体機能性の非多孔性微視的多層コラーゲンホイル生物基質を提供し、それで覆い、それで分離する工程を含む方法に関する。
