Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performedin situin a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subjectin situto activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.本發明係關於用於修飾可介導生物活性或與生物活性有關之標靶結構，包括治療由標靶結構介導或與標靶結構有關之病狀、病症或疾病的產品、組合物、系統及方法，該標靶結構諸如為病毒、細胞、次細胞結構或細胞外結構。該等方法可以非侵入性方式藉由將在表面之至少一部分上具有金屬外殼之奈米粒子置放於個體體內之標靶結構附近且向個體施加起始能量，由此直接或經由調節劑對該標靶結構產生影響或改變而於原位進行。該奈米粒子經組態成在曝露於第一波長λ1之輻射時產生能量高於該第一波長λ1的第二波長λ2之輻射。該等方法可進一步藉由視情況在一或多種電漿子活性劑存在下，向個體原位施加起始能量以直接或經由能量調節劑活化醫藥劑，由此對該標靶結構產生影響或改變而進行。本發明係關於用於實踐此等方法之含有經調配或經組態之產品或組合物的套組及系統。
