Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.本發明係關於用於修飾介導生物活性或與生物活性有關之靶結構，包括治療由靶結構介導或與靶結構有關之病況、病症或疾病的產品、組合物、系統及方法，靶結構諸如病毒、細胞、亞細胞結構或胞外結構。該等方法可以原位非侵入方式藉由向個體施加起始能量，因此直接或經調節劑對靶結構產生作用或改變而進行。該等方法另可藉由視情況在一或多種電漿子活性劑(plasmonics active agents)存在下，向個體原位施加起始能量以直接或經能量調節劑活化醫藥劑，因此對靶結構產生作用或改變而進行。用於實踐此等方法之含有經調配或經組裝(configured)之產品或組合物的套組及系統。
