GANTIER; MICHAEL PAUL MARIE;GANTIER, MICHAEL PAUL MARIE;TONG, STEPHEN;WILLIAMS, BRYAN RAYMOND GEORGE
发明人:
GANTIER, MICHAEL PAUL MARIE,TONG, STEPHEN,WILLIAMS, BRYAN RAYMOND GEORGE
申请号：
EP09709623
公开号：
EP2250183A4
申请日:
2009.02.16
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention relates to a double-stranded siRNA molecule that is capable of silencing gene expression as well as inducing an immune response. The molecule comprises a sense strand and an antisense strand, wherein the antisense strand comprises a first nucleotide sequence that is specifically complementary to mRNA transcribed from a target gene, and the sense strand comprises a second nucleotide sequence that is substantially or perfectly complementary to the antisense strand with the exception that the second nucleotide sequence comprises at least one immunostimulatory motif comprising two or more non-complementary nucleotides. Such a molecule may be utilized in a method of treating or preventing a disease or condition (such as a viral infection, a bacterial infection, or cancer) in a subject.
