One of the aspects of the invention is directed toward a method of treating or preventing acute brain or nerve injury in a subject, comprising administering an effective amount of posiphen, or a pharmaceutically acceptable salt of posiphen, to the subject in need thereof. Similarly, another aspect of the invention is directed toward a use of posiphen, or a pharmaceutically acceptable salt of posiphen, for the treatment or prevention of acute brain or nerve injury. Preferably, the posiphen in the method or use of the invention is posiphen tartrate.本發明的一個方面是針對一種治療或預防個體的急性腦部或神經損傷的方法,其包含向有需要的所述個體投予有效量的珀斯芬(posiphen)或珀斯芬的藥學上可接受的鹽。類似地,本發明的另一方面是針對珀斯芬或珀斯芬的藥學上可接受的鹽的用途,其用於治療或預防急性腦部或神經損傷。優選地,本發明的方法或用途中的珀斯芬是珀斯芬酒石酸鹽。