The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.本發明提供新蛋白酶抗性多肽以及治療、改善或預防與關節損傷相關之病況(包含急性關節損害及關節炎)之組合物及方法。