Novel oxysterol analogue, Oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis

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专利权人:

The Regents of the University of California

发明人:

Parhami, Farhad,Jung, Michael E.,Stappenbeck, Frank,Pierce Jr., William M.,Taylor, K. Grant,Merten, Kevyn E.

申请号：

AU2013260057

公开号：

AU2013260057A1

申请日:

2013.03.15

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

This invention relates, e.g., to a synthetic compound, Oxy149, having the structure (Formula I) or a bioactive or pharmaceutical composition comprising Oxy149 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g. bone disorders, obesity, cardiovascular disorders, and neurological disorders. Oxy149 can be delivered either locally or systemically.

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