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AGENT FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA
专利权人:
RIKEN
发明人:
Fumihiko Ishikawa,Yoriko Saito,Toshinobu Hashizume,Yasuko Koda,Hitomi Yuki
申请号:
US14417250
公开号:
US20150210698A1
申请日:
2013.07.29
申请国别(地区):
US
年份:
2015
代理人:
摘要:
This invention relates to an agent for treating or inhibiting recurrence of acute myeloid leukemia and an agent for inhibiting growth of leukemia stem cells comprising a compound represented by formula (I) or a salt thereof:wherein Ar1 and Ar2 each represent aryl or heteroaryl; L represents O, S, NH, NHCO, or CONH; X represents CH or N; Y represents C1-3-alkylene; Z1 represents hydrogen, C1-6-alkyl, amino-C1-6-alkyl, C1-6-alkylamino-C1-6-alkyl, di(C1-6-alkyl)amino-C1-6-alkyl, hydroxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl, or carboxy-C1-6-alkyl; and Z2 represents C1-6-alkyl, amino-C1-6-alkyl, C1-6-alkylamino-C1-6-alkyl, di(C1-6-alkyl)amino-C1-6-alkyl, hydroxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl, or carboxy-C1-6-alkyl, Z1 and Z2 may, together with adjacent nitrogen, form a heterocyclic group containing as a ring member one or more hetero atoms, in addition to the nitrogen adjacent to Z1 and Z2.
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