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СПОСОБ ЛЕЧЕНИЯ ОСТРОГО МИЕЛОИДНОГО ЛЕЙКОЗА И/ИЛИ ОСТРОГО ЛИМФОБЛАСТНОГО ЛЕЙКОЗА С ПОМОЩЬЮ ТИЕНОТРИАЗОЛОДИАЗЕПИНОВЫХ СОЕДИНЕНИЙ
专利权人:
ОНКОЭТИКС ГМБХ (CH)
发明人:
НОУЭЛ Кэй (US),РИВЕЙРО Мария Е. (FR)
申请号:
RU2016146099
公开号:
RU2016146099A
申请日:
2015.05.01
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
A method of treating acute myeloid leukemia, acute lymphoblastic leukemia, high risk myelodysplastic syndrome, and/or HR-MDS/AML in a mammal by administering a solid dispersion comprising an amorphous thienotriazolodiazepine compound of the Formula (1) wherein R1 is alkyl having a carbon number of 1-4, R2 is a hydrogen atom a halogen atom or alkyl having a carbon number of 1-4 optionally substituted by a halogen atom or a hydroxyl group, R3 is a halogen atom phenyl optionally substituted by a halogen atom, alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1-4 or cyano —NR5-(CH2)m R6 wherein R5 is a hydrogen atom or alkyl having a carbon number of 1-4, m is an integer of 0-4, and R6 is phenyl or pyridyl optionally substituted by a halogen atom.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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