Use of formulation comprising (a) isocyanate functional prepolymers obtained from (a1) aliphatic isocyanates and (a2) polyols with a number average molecular weight of >= 400 g/mol and an average hydroxyl functionality of 2-6 (b) a hardener comprising (b1) an amino functional aspartic acid ester compound (I) and (b2) organic fillers having viscosity of 10-6000 mPas at 23[deg] C, according to DIN 53019 and (c) optionally reaction product of (a) with (I) and/or organic filler, for blocking the leakage of blood or tissue fluids, or to seal the leak in the cell tissues, is claimed. Use of formulation comprising (a) isocyanate functional prepolymers obtained from (a1) aliphatic isocyanates and (a2) polyols with a number average molecular weight of >= 400 g/mol and an average hydroxyl functionality of 2-6 (b) a hardener comprising (b1) an amino functional aspartic acid ester compound of formula (X-[-NH-CH(CH 2-COOR 2)-)-COOR 1] n) (I) and (b2) organic fillers having viscosity of 10-6000 mPas at 23[deg] C, according to DIN 53019 and (c) optionally reaction product of (a) with (I) and/or organic filler, for blocking the leakage of blood or tissue fluids, or to seal the leak in the cell tissues, is claimed. X : an n-valent organic residue, which is obtained by removing the primary amino group of an n-valent amine R 1, R 2organic residue, which shows no Zerewitinoff-active hydrogen and n : 2. ACTIVITY : Hemostatic. The hemostatic activity of the formulation was tested by opening the right ear vein of the pig over 10 mm using scalpel and applying the formulation. The result showed that the formulation stopped the bleeding within 1 minute. MECHANISM OF ACTION : None given.
