Provided are a 20(R)-ginsenoside Rg3 multiacylated derivative, as represented by the formula (I), and a preparation method and antitumor application of same. R=CH3(CH2)nCO, and n=0 to 5.L'invention concerne un dérivé 20(R)-ginsénoside Rg3 multiacylé, représenté par la formule (I), son procédé de préparation et son application antitumorale. R=CH3(CH2)nCO, et n = 0 à 5.如式(Ⅰ)所示的20(R)-人参皂苷Rg3多酰基化衍生物、制备方法及其抗肿瘤应用: R=CH 3(CH 2)nCO n=0~5。