EINZIGER, MICHAEL,恩济格 麦可,恩濟格 麥可,SIMPSON, ANN MARIE,辛普森 安 玛丽,辛普森 安 瑪麗
申请号：
TW108120627
公开号：
TW202000194A
申请日:
2019.06.14
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involveMalassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.本發明係關於用於調控皮膚色素沈著及治療或預防個體之UV誘導皮膚損傷、紅斑、皮膚老化、曬傷及色素過多的化合物、組合物及方法。本發明之化合物、組合物及方法一般涉及衍生自馬拉色菌(Malassezia)之化合物，其包括馬拉色菌素(malassezin)及靛玉紅(indirubin)，及/或其化學類似物。本文所揭示之化合物及組合物之其他應用包括(但不限於)：改良由色素過多病症引起之色素過多，誘導黑素細胞凋亡及調控芳基烴受體(AhR)活性、黑素生成、黑素產生、黑素體生物合成、黑素體轉移、黑素細胞活性及黑素濃度。
