EINZIGER, MICHAEL,恩济格 麦可,恩濟格 麥可,SIMPSON, ANN MARIE,辛普森 安 玛丽,辛普森 安 瑪麗
申请号：
TW108112943
公开号：
TW201946621A
申请日:
2019.04.12
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involveMalassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.本發明係關於用於調節個體之皮膚色素沉著及治療或預防UV誘發之皮膚損害、紅斑、皮膚老化、曬傷及色素沉著過度之化合物、組合物及方法。本發明之該等化合物、組合物及方法通常涉及馬拉色菌(Malassezia)衍生化合物，包含馬拉斯嗪(malassezin)及靛玉紅(indirubin)及/或其化學相似物。本文所揭示之該等化合物及組合物之其他應用包含(但不限於)改良由色素沉著過度病症引起之色素沉著過度，誘發黑色素細胞凋亡，及調節芳基烴受體(AhR)活性、黑色素生成、黑色素產生、黑素體生物生成、黑素體轉移、黑色素細胞活性及黑色素濃度。
