What formula is closed in system of the present invention(I)Its optical isomeric compound of compound,And its addition salts with pharmaceutically acceptable acid,Wherein: Ak1 indicates alkyl chain,X expressions-(CH2)m-,-CH(R)-,-N(R)-,-CH2-N(R)-,-N(R)- CH2- or-CH2-N(R)-CH2-,M and R systems are as defined in description,When X expressions-(CH2)m-,-CH(R)-,-N(R)-,-CH2-N(R)Or-N(R)When-CH2-,R1 and R2 respectively indicate H,Or work as X expressions-CH2-N(R)When-CH2-,R1 and R2 are formed together key,R3 indicates NH2,Cy-NH2,Cy-Ak3-NH2 or piperidin-4-yl,Cy and Ak3 systems are as defined in description,R4 and R5(Its etc. may be the same or different)It is each to indicate H or F. What medicament is closed in system of the present invention.Compuestos de formula (I)<；/p>； <；p>；ESPACIO PARA LA FÓRMULA<；/p>； <；p>；en la que:<；/p>； <；p>；Ak1 representa una cadena alquilo,<；/p>； <；p>；X representa -(CHz)m-, -CH(R)-, -N(R)-, -CHz-N(R)-, -N(R)-CHz- o -CHz-N(R)-CHz-,<；/p>； <；p>；m y R son tales como se han definido en Ia descripcion,<；/p>； <；p>；R1 y R2 representan cada uno H cuando X representa -(CHz)m-, -CH(R)-, -N(R)-, -CHz-N(R)- oN(R)-CHz-,<；/p>； <；p>；o bien forman juntos una unión cuando X representa -CHz-N(R)-CHz-,<；/p>； <；p>；R3 representa NHz, Cy-NHz, Cy-Ak3-NHz o piperidin-4-ilo,<；/p>； <；p>；Cy y Ak3 son tales como se han definido en Ia descripcion,<；/p>； <；p>；R4 y R5, idénticos o diferentes, representan cada uno H o F, sus isomeros ópticos, así como sus sales de adición a un ácido farmacéuticamente aceptable.<；/p>； <；p>； <；/p>；
