In various embodiments, a disposable loading unit (16) for a surgical stapling instrument (10) can include an anvil (20), a staple cartridge (220), a staple cartridge channel (218) for operably supporting the staple cartridge (220), and a connector (1017) for removably attaching the disposable loading unit to the surgical instrument. In at least one embodiment, a first staple cartridge can be replaced with another staple cartridge after the first staple cartridge has been at least partially expended. In various embodiments, a staple cartridge can include a staple driver (232) for deploying staples from the staple cartridge (220) and a cutting member (280) for incising tissue, wherein a new staple driver and a new cutting member can be provided with each new staple cartridge. The anvil (20) can be removably attachable to the disposable loading unit (16) such that a new anvil can be utilized with a new staple cartridge.
