THE PRESENT INVENTION RELATES TO COMPOUNDS WITH THE FORMULA (Ι), (ΙΙ), (ΙΙΙ) OR (ΙV): WHEREIN R¹, R², R³, R⁴,R⁵, R⁶, R⁷, X AND Z ARE AS DEFINED HEREIN, AND ALSO TO PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS, AS WELL AS METHODS OF USE OF THE COMPOUNDS FOR TREATMENT OF DISORDERS ASSOCIATED WITH HUMAN 11-β- HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME AND FOR THE PREPARATION OF A MEDICAMENT WHICH ACTS ON THE HUMAN 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME.