DAL POZZO ALMA,TINTI MARIA ORNELLA,ALLOATTI DOMENICO,VESCI LOREDANA,DALLAVALLE SABRINA,NI MING HONG,PENCO SERGIO,MERLINI LUCIO,GIANNINI GIUSEPPE,PISANO CLAUDIO
申请号：
IN2947/KOLNP/2006
公开号：
IN250556B
申请日:
2006.10.12
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors αv⓷ and αv⓹ and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
