A p53 degradation inducing molecule which can induce degradation of p53 proteins or p53 composites, and a pharmaceutical composition containing said p53 degradation inducing molecule are provided. This p53 degradation inducing molecule is a conjugate of a p53 affinity molecule which has affinity for p53 proteins or p53 composites, and a proteolysis induction tag which has affinity for protease and which does not inhibit proteolysis of proteins by protease.本發明提供一種p53分解的誘導分子及包含該p53分解的誘導分子之醫藥組成物，該p53分解的誘導分子是p53親和性分子與蛋白質分解的誘導標記之共軛物，且能夠誘導p53蛋白或p53複合物分解，該p53親和性分子對於前述p53蛋白或p53複合物具有親和性，該蛋白質分解的誘導標記對於蛋白酶具有親和性並且不會抑制藉由蛋白酶來實行的蛋白質分解。
