This provides an advantageous method of production of a Derivative of imidazole, which is suitable for Industrial Production. The Compound of formula (1) is produced by reacting a compound of formula (2) with a Grignard Reagent or a Reagent and a Magnesium Lithium Reagent and then the resulting Compound by reacting with the compound of formula (3).The compounds of the present are useful in the Prevention or treatment of diseases in which androgens or estrogens are Aggravating factors.Claim 1: a production method of a compound represented by the formula (1) where pg is a protecting group or one of its Salts, characterized in that it comprises a step (i): a stage of reaction of a compound represented by the formula (2) where R1 is a iodine Atom or N atom of BromineA compound represented by the formula: R2 - MGX where R2 is alkyl group or an aryl Group C1 - C6 6 - 12； and X is a Chlorine Atom, an atom of Bromine or iodine Atom, or a compound represented by the formula: R2R2 mg where R2 is a group alkyl or aryl Group C1 - C6 6 - and 12； R 2 is as defined above,And a compound represented by the formula: R3 - li where R3 is an alkyl group or an aryl Group C1 - C6 6 - 12； and then the resulting Compound reaction with a compound represented by the formula (3) where pg is as defined earlier； or one of its Salts.La presente proporciona un método de producción ventajoso de un derivado de imidazol, que es apropiado para la producción industrial. El compuesto de fórmula (1) se produce haciendo reaccionar el compuesto de fórmula (2) con un reactivo de Grignard o un reactivo de magnesio y un reactivo de litio y luego haciendo reaccionar del compuesto resultante con el compuesto de fórmula (3). Los compuestos de la presente son útiles en la prevención o tratamiento de enfermedades en las que los andrógenos o estrógenos constituyen factores agravantes.Reivindicación 1: Un método de producción de un compuesto representado por la fórmula (1) en donde PG es un grupo protector, o una de
