Novel indolizine derivative, process for its preparation and therapeutic composition containing it农业专利-农业学术服务平台

发明人:: ゴーテイエ，パトリツク,マルシオニ，ダビツド,ロコン，アラン,トネール，ベルナール,バニヨン，ジヤン,ゴーテイエ,パトリツク,マルシオニ,ダビツド,ロコン,アラン,トネール,ベルナール,バニヨン,ジヤン

摘要：: 3-Benzoylindolizine derivatives (I) and their salts are new. 3-Benzoylindolizine derivatives of formula (I) and their salts are new. X : (CH 2) n or CH 2-Z(CH 2) 2； n : 1-6； Z : O(CH 2) m； m : 0-3； R 1>； : 1-8C (cyclo)alkyl； A : NR 3>；R 4>；； R 3>；, R 4>； : H, 1-6C (cyclo)alkyl, 1-3C alkyl substituted by 3-6C cycloalkyl, (CH 2) l-O-B'； or NR 3>；R 4>； : form 4-6 membered heterocycle optionally containing one or more additional N or O (optionally substituted by one or more 1-6C (cyclo)alkyl)； B' : H or (CH 2) k； l,k : 2 or more； R2 : hydrogen or 1-6C linear, branched or cyclic alkyl. Provided that l+k does not exceed 6. An independent claim is included for a method for preparing (I). [Image] ACTIVITY : Cardiant； Antianginal； Hypotensive； Antiarrhythmic. MECHANISM OF ACTION : alpha -Adrenergic inhibitor； beta -Adrenergic inhibitor； Cardiac ion channel inhibitor.