Key intermediates and impurities of the synthesis of apixaban: apixaban glycol esters
- 专利权人:
- 发明人:
- Elena Brasola,Filippo Tomasi
- 申请号：
- US15038936
- 公开号：
- US09920051B2
- 申请日:
- 2015.02.18
- 申请国别(地区):
- US
- 年份:
- 2018
- 代理人:
- 摘要：
- Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
- 来源网站：
- 中国工程科技知识中心
