JAYAMANI, M.,SRIDHAR, Bhuvaneswari,KUMAR, K. Santha,BABU, R. Madhu
申请号：
IBIB2014/059675
公开号：
WO2014/141092A3
申请日:
2014.03.12
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
An improved process for the preparation of Tenofovir disoproxil Fumarate using Wittig reagents as phase transfer catalyst. Another object of the invention is to provide a simple, cost effective process for the preparation of Tenofovir Disoproxil Fumarate with high purity and without the formation of undesired impurities. Yet another object of the present invention is to provide an efficient process which avoids the use of large quantities of catalysts. Further object of the invention is to provide a process for preparation of Tenofovir Disoproxil Fumarate in high yield and purity in short span of time, thereby substantially minimize the product degradation.Procédé amélioré de préparation de fumarate de ténofovir disoproxil utilisant des réactifs de Wittig comme catalyseur de transfert de phase.
