The present invention provides a genuine epilepsy model animal as an improvement over conventional epilepsy model animals which are socalled seizures model animals mainly causing seizure attacks to be forcibly induced. Also provided is a method that allows for easy identification of the recombinants. The model non-human mammalian animal for human epilepsy according to the present invention is a human epilepsy model non-human mammalian animal, such as a rat model, that has the same genetic defects as those in human epilepsy. The model non-human mammalian animal has a mutated gene obtained by introducing a genetic mutation to the non-human mammalian DNA of the ±4 subunit ( CHRNA 4) or ²2 subunit ( CHRNB 2) of the neuronal nicotinic acetylcholinergic receptor gene associated with human autosomal dominant nocturnal frontal lobe epilepsy, and by introducing a specific probe. The human epilepsy model non-human mammalian animal of the present invention allows for easy identification of the recombinants.
